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Functional protocols emphasize the importance of evaluating infectious, inflammatory, metabolic, hormonal, toxic, and genetic variants, and have shown modest success in preventing, and in some cases partially reversing, cognitive decline, as reported in a pilot study published in the Journal of Alzheimers Disease (Toups et al., 2022)

Equivalent numbers of age-matched unsegregated flies were used for all experiments except survival assay

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GRM2 regulates functional integration of adult-born DGCs by paradoxically modulating MEK/ERK1/2 pathway

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